Science & Research

ActivAMP has been the subject of multiple clinical studies to not only confirm the variety of benefits it offers, but to reflect Gencor's commitment to providing scientifically-proven, effective ingredients.

Study #1

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  • Science Inside: Rao A, Clayton P, Briskey D. The effect of an orally‐dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double‐blind, randomised, placebo‐controlled study. J Hum Nutr Diet. 2022;35:583–589. 10.1111/jhn.12936
  • Study Design: Randomized, double-blind, placebo-controlled trial
  • Subjects: 117 overweight men and women
  • Intervention: 225mg of ActivAMP twice daily (450mg/day)
  • Study Duration: 16 weeks
  • Reduction in body weight
  • Reduction in Body Mass Index
  • Reduction in Total Dat Mass
  • Reduction in Vesceral Fat for Men
  • Reduction in Gynoid Fat for women
  • Reduction in the levels of TNF-Alpha, a biomarker for inflammation

Study #2

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  • Science Inside: Ahn, Yejin, et al. “Effects of gypenoside L-containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double-blind, placebo-controlled, randomized trial.” (2023)
  • Study Design: Randomized, double-blind, placebo-controlled trial
  • Subjects: 98 healthy adult men and women
  • Intervention: 450mg of ActivAMP daily (450mg/day)
  • Study Duration: 12 weeks

When compared to placebo, there was significant improvement in:

  • VO2 max (maximal oxygen consumption during exercise)
  • 1.10 ml/kg/min (p=0.001)
  • Trend towards for significance* for:
  • O2 pulse (oxygen consumes per heartbeat)
  • Market related to endothelial function

Study #3

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  • Science Inside: Jäger, Sibylle, et al. “AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α.” Proceedings of the National Academy of Sciences 104.29 (2007): 12017-12022.
  • Study Result: AMPK has been noted to phosphorylate peroxisome-proliferator-activated receptor γ (PPRA-γ) coactivator 1α (PGC-1α) in skeletal muscle6. The study on ActivAMP saw an increase in mRNA PGC-1α expression in skeletal muscle cells as well4. PGC-1α facilitates mitochondrial biogenesis as well as the oxidation of fatty acids in skeletal muscle

Study #4

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  • Science Inside: Kim, Yoon Hee, et al. “Efficacy of Gynostemma pentaphyllum extract in anti-obesity therapy.” Rec Nat Prod 14 (2020): 116-28.
  • Study Result: Mechanism of Action: Skeletal Muscle ActivAMP® activated AMPK in L6 cells (immortalized rat skeletal myoblast cells)
    AMPK activation in turn:
    improved glucose uptake of skeletal through increased GLUT-4 (glucose transporter type 4)